| Autor(en) |
Titel |
Quelle |
Links |
| Überall M, Haupt K, Hertzberg H, Langer T, Meier W, Huk W, Beck J, Wenzel D |
Quantitative EEG in long-term survivors of acute lymphoblastic leukemia. |
Pediatr Neurol 1996, 15: 293 |
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| Überall M, Haupt K, Meier W, Hertzberg H, Beck J, Wenzel D |
P300 abnormalities in long-time survivors of acute lymphoblastic leukemia in childhood--side effects of CNS prophylaxis? |
Neuropediatrics 1996, 27: 130 |
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| Überall M, Hertzberg H, Meier W, Langer T, Beck J, Wenzel D |
Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group. |
Neuropediatrics 1996, 27: 194 |
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| Überall M, Skirl G, Strassburg H, Wenzel D, Hertzberg H, Langer T, Meier W, Berger-Jones K, Huk W, Korinthenberg R, Beck J |
Neurophysiological findings in long-term survivors of acute lymphoblastic leukaemia in childhood treated with the BFM protocol 81 SR-A/B |
Eur J Pediatr 1997, 156: 727 |
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| Uderzo C, Balduzzi A, De Lorenzo P, Valsecchi M, Gadner H, Klingebiel T, Zimmermann M, Schrappe M |
Prospective study on allogeneic bone marrow transplantation (allo BMT) versus chemotherapy (chemo) for very high-risk (VHR) childhood acute lymphoblastic leukaemia in first complete remission. |
Bone Marrow Transplant 2001, 28 Suppl 1:S22-S24 |
 |
| Ulmer A, Tabea Tauer J, Glauche I, Jung R, Suttorp M |
TK Inhibitor Treatment Disrupts Growth Hormone Axis: Clinical Observations in Children with CML and Experimental Data from a Juvenile Animal Model. [+] |
Klinische Padiatrie 2013, 225: 120 |
|
| Long-term treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) exerts off-target effects on bone growth by either impaired growth hormone (GH) action or osseous modelling impairment.Body height and the GH-related parameters insulin-like growth factor 1 (IGF-1) and insulin-like growth factor-binding protein 3(IGFBP-3) were determined repetitively 3-monthly over 2 years in 21 pediatric CML-patients on standardized imatinib treatment. In an animal model 4-week-old male Wistar rats were exposed over 10 weeks to imatinib, dasatinib, or bosutinib at varying concentrations via the drinking water. Blood was collected at prepubertal age, pubertal age, and at adult age, respectively, and animals' serum levels of IGFBP-3 were measured.Independent from treatment duration patients exhibited IGF-1 and IGFBP-3 levels almost exclusively in the very low range when compared to age-matched references. No clear pattern of rising or falling IGF-1 and IGFBP-3 levels was observed. In rats, compared to controls, serum IGFBP-3 was significantly lowered for all TKIs tested, at all concentrations applied, and at all ages under investigation.Besides direct off-target effects on the growing skeleton, TKI treatment also results in lowered blood levels of IGF-1 and IGFBP-3.A juvenile rat model predicts this side effect for dasatinib and bosutinib. Thus, growth and GH- related parameters should be monitored regularly in pediatric patients with CML on TKIs. |
| United Nations Scientific Committee on the Effects of Atomic Radiation |
SOURCES AND EFFECTS OF IONIZING RADIATION. |
UNSCEAR 2000 REPORT Vol. II |
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| Uppenkamp M, Feller AC |
Classification of malignant lymphoma. |
Onkologie 2002, 25: 563 |
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| Urbano-Ispizua A, Schmitz N, de Witte T et al., European Group for Blood and Marrow Trans-plantation |
Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: definitions and current practice in Europe. |
Bone Marrow Transplant 2002, 29: 639 |
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| Urban C, Lackner H, Müller E, Benesch M, Strenger V, Sovinz P, Schwinger W |
Stem cell transplantation in 6 children with parvovirus B19- induced severe aplastic anaemia or myelodysplastic syndrome. [+] |
Klinische Padiatrie 2011, 223: 332 |
|
| Parvovirus B19 (PVB19) induced severe aplastic anaemia (SAA) or myelodysplastic syndrome (MDS) is rare, and haematopoietic stem cell transplantation (HSCT) in this condition has not been reported so far. 6 children with SAA (n=4) or MDS (n=2) caused by acute PVB19 infection underwent HSCT under the protection of intravenous immunoglobulines. The 4 children with SAA received matched HLA bone marrow from a sibling (n=3) or peripheral unrelated blood stem cells (n=1). 1 patient had delayed erythrocyte engraftment, whereas 3 patients had an uneventful transplantation course. HSCT in one of the 2 children with MDS was complicated by poor graft function, the other patient engrafted without complications. In conclusion, HSCT in children with PVB19 induced SAA or MDS is feasible, even though some patients may develop delayed engraftment or prolonged poor graft function. |
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